The Complement System in Spondyloarthritis: What Do We Know?

نویسندگان

چکیده

Spondyloarthritis (SpA) encompasses a group of rheumatologic diseases, including axial spondyloarthritis (axSpA), psoriatic arthritis, arthritis with associated inflammatory bowel disease (i.e. Crohn’s and ulcerative colitis), reactive undifferentiated SpA, which all share certain clinical, biological genetic features. However, the pathogenesis remains largely unexplained. Recent evidence suggests an autoinflammatory component disease. The complement system is cornerstone innate immune system. This review aims to evaluate current knowledge in SpA. Animal models have shown that activation axSpA. Complement proteins L-ficolin H-ficolin levels are elevated patients axSpA, factor C3 decrease after initiation tumour necrosis factor-inhibitor therapy. Associations activity inconsistent, as one study found serum factors C4 did not differ different Bath Ankylosing Spondylitis Disease Activity Index scores but, another study, were baseline Score C-reactive protein improvement treatment inhibitor. Future studies should focus on various SpA entities, involvement progression under clinically relevant conditions.

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ژورنال

عنوان ژورنال: Rheumatology

سال: 2022

ISSN: ['1462-0324', '1462-0332']

DOI: https://doi.org/10.17925/rmd.2022.1.2.50